British Association for Cytopathology June 2025 Case Study
Persistent High Grade Dyskaryosis in cytology with Low Grade Histology in a Patient with Vaginal Adenosis and Unusual Cervical Gastric Metaplasia: A Long Term Diagnostic Challenge
Dr. Supriya Dhar, Locum Consultant Cytopathologist Manchester University NHS Foundation Trust
- We present a complex case involving both a likely DES associated glandular
abnormality and persistent cytology histology discordance, necessitating
multidisciplinary evaluation over a long period of time. - A woman in her mid fifties, with probable maternal DES exposure, has been under
gynaecological follow up for 17 years. - Vaginal biopsies confirmed vaginal adenosis.
- A hysterectomy specimen also showed features in keeping with vaginal adenosis.
